erythromycin thiocyanate
erythromycin thiocyanate
CAS: 7704-67-8
Molecular Formula: C38H68N2O13S
erythromycin thiocyanate - Names and Identifiers
| Name | erythromycin thiocyanate |
| Synonyms | ERYTHROMYCIN THIOCYNATE ERTHROMYCIN THIOCYANATE erythromycin thiocyanate ERYTHROMYCIN THIOCYANATE ErythroMicyn thiocyanate Erythromycin Thiocyanante ErythroMycin Thiocyanate CGMP ERYTHROMYCIN THIOCYANATE CP2000 Erythromycin, thiocyanate (salt) ERYTHROMYCIN THIOCYANATE NOT LESS THAN 750 U OF ERYFHROMYCIN PER MG |
| CAS | 7704-67-8 |
| EINECS | 231-723-1 |
| InChI | InChI=1/C37H67NO13.CHNS/c1-14-25-37(10,45)30(41)20(4)27(39)18(2)16-35(8,44)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(9,46-13)31(42)23(7)48-26;2-1-3/h18-26,28-32,34,40-42,44-45H,14-17H2,1-13H3;3H/t18-,19-,20+,21+,22-,23+,24+,25-,26+,28-,29+,30-,31+,32-,34+,35-,36-,37-;/m1./s1 |
erythromycin thiocyanate - Physico-chemical Properties
| Molecular Formula | C38H68N2O13S |
| Molar Mass | 793.02 |
| Melting Point | 166-167 °C |
| Boling Point | 818.4°C at 760 mmHg |
| Flash Point | 448.8°C |
| Vapor Presure | 4.94E-31mmHg at 25°C |
| Appearance | Crystalline |
| Storage Condition | -20°C |
| In vitro study | Erythromycin inhibits growth of P. falciparum with IC 50 and IC 90 values of 58.2 μM and 104.0 μM, respectively. |
erythromycin thiocyanate - Reference Information
| macrolide antibiotic | erythromycin thiocyanate is the thiocyanate of erythromycin, a commonly used macrolide antibiotic, for the treatment of gram-positive bacteria and mycoplasma infection, in foreign countries has been widely used as "animal growth promoter", it and tylosin, tetracycline hydrochloride and oxytetracycline and listed as China's four major export veterinary antibiotic products. In addition, this product is also an important intermediate for the synthesis of mainstream macrolide antibiotic products erythromycin, roxithromycin, azithromycin and clarithromycin. China from the 20th century 80-90's began to produce erythromycin thiocyanate, but the output is very low is less than 100 tons, by the year 2007, erythromycin thiocyanate has become China's macrolide antibiotics in the largest export varieties, production capacity has exceeded 10000 tons. The antibacterial spectrum of erythromycin thiocyanate is similar to that of Benzylpenicillin, and it has a strong effect on Staphylococcus aureus, Streptococcus and Pneumonia coccus in gram-positive bacteria, and has a strong effect on Pasteurella multocida, brucella also has a certain role; In addition, this product is also effective against mildew, Rickettsia, leptospira, actinomycetes, Nocardia, but for Escherichia coli, salmonella and other intestinal negative bacilli have no effect. Mainly used for drug-resistant Staphylococcus aureus, hemolytic streptococcus caused by serious infections, such as Pneumonia, sepsis, endometritis, mastitis, etc.; The mold body caused by poultry chronic respiratory disease, pig mold body Pneumonia also has good curative effect, also used for the treatment of dog, cat Nocardia disease; Can also control the white head and mouth disease of grass, grass, silver carp, bighead carp and other fish, grass carp, carp bacterial gill disease, silver carp, bighead carp and other fish white skin disease and tilapia streptococcus disease. |
| biological activity | Erythromycin thioate is a macrolide antibiotic produced by actinomycete Streptomyces erythreus, which has a wide range of antibacterial activity. Erythromycin thiocyanate acts by binding to the 50S ribosomal subunit of bacteria and inhibits the synthesis of RNA-dependent proteins by blocking transpeptide and/or translocation reactions without affecting the synthesis of nucleic acids. |
| Target | Bacterial; RNA-dependent protein synthesis |
| uses | is mainly used for the treatment of penicillin-resistant Staphylococcus, streptococcus and other infections antibiotics. |
Last Update：2024-04-09 21:32:08
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View History
erythromycin thiocyanate
19168-23-1
1217862-57-1
33939-97-8
14332-62-8
36239-09-5
2-(2-thienyl)pyridine
全氟辛基磺酰氟
羟基乙叉二膦酸
二甘醇二丁醚
19168-23-1
1217862-57-1
33939-97-8
14332-62-8
36239-09-5
2-(2-thienyl)pyridine
全氟辛基磺酰氟
羟基乙叉二膦酸
二甘醇二丁醚